Obregón began his professional career as a radio announcer in the late 1950s. His screen career began in the 1960s, and he has continued to work in films, TV and the stage ever since. Obregón was one of the actors who rebelled against the ANDA actors' union in the 1970s, forming the Independent Actors Syndicate, a rival group which eventually failed. He received a Best Actor Ariel nomination for Esmeralda Comes by Night (1997), and Best Supporting Actor Ariel nominations for El otro crimen (1988) and _Actas de Marusia (1975)_.