Luisi Pistilli's most notable stage successes were roles in "The Threepenny Opera", "St. Joan of the Stockyards" and a 1972 production, "Lulu". In 1991 he reprised his role in "Lulu" in the first professional collaboration with actress-singer Milva, his partner in previous plays as well as in a four-year offstage relationship. Pistilli's most memorable roles were in Francesco Rosi's Illustrious Corpses (1976), Lino Del Fra's Antonio Gramsci: i giorni del carcere (1977), Carlo Lizzani's Italo-Bulgarian co-production The Bandit (1969) and Sergio Leone's For a Few Dollars More (1965) and The Good, the Bad and the Ugly (1966), in which he played priest Pablo Ramirez, the brother of Eli Wallach's character Tuco. He also worked frequently in TV, including the Mafia series La piovra (1984), directed by Luigi Perelli.